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王晓雪
所系名称
中国科学院南海海洋研究所,中国科学院热带海洋生物资源与生态重点实验室
性别
专业名称
海洋生物学
技术职务
责任研究员
行政职务
Mail地址
xxwang@scsio.ac.cn
指导博士生总数
8
指导硕士生总数

8

通讯地址
广州市新港西路164号2号楼302A
目前博士生数
3
目前硕士生数
3
邮政编码
510301
研究方向
微生物生理代谢与环境适应机制。
研究工作
  主要从事微生物的环境适应机制研究。近年来,围绕模式微生物和海洋微生物基因组中的原噬菌体、基因岛等可移动遗传元件和毒素-抗毒素系统,深入解析了原噬菌体和基因岛的转移过程及环境效应,鉴定出多个新类型的毒素-抗毒素系统并阐述其生理功能,揭示海洋微生物通过形成生物膜抑制金属腐蚀并抵抗污损生物新机制。这些研究有助于深入了解基因的水平转移在微生物适应性进化中的作用及开发通过海洋生物膜进行防腐的生物制剂具有重要的理论和现实意义。
获奖情况

1. 国家杰出青年基金项目获得者(2016)

2. 中科院特聘研究员骨干人才(2017)

指导研究生情况

在读博士研究生:王伟权(2017直博生)、王蕴洁(2018直博生)、陈喆(2019直博生)

在读硕士研究生:周一清(2017)、刘天朗(2018)、林世团(2019)

已培养博士研究生5名;硕士研究生5名

个人简介

学习经历

1996.09-2000.07:中国海洋大学,食品科学系,学士

2002.05-2006.12:美国Texas A&M University,博士

 

工作经历

2007.01-2008.01:美国Rutgers UniversityResearch Associate

2008.03-2011.11:美国Texas A&M UniversityResearch Associate

2011.12-至今:中国科学院南海海洋研究所,责任研究员

 

学术兼职

1. 中国海洋湖沼学会微生物海洋学分会理事(2017-2020

2. 广东省遗传学会理事(2018-2022

3. 中国遗传学会微生物遗传专业委员会委员(2019-2023

4.《中国科学:地球科学》编委(2012-2022

5. Frontiers in Microbiology编委(2015-2020

科研成果

论文发表

39.PX Wang, D He, BY Li, YX Guo, WQ Wang, XJ Luo, XY Zhao, Wang XX*. Eliminating mcr-1-harbouring plasmids in clinical isolates using the CRISPR/Cas9 system. Journal of Antimicrobial Chemotherapy. 2019, 74(9), 2559-2565

38. Liu XX, Tang KH, Zhang DL, Li YM, Liu Z, Yao JY, Wood TK, Wang XX*. Symbiosis of a P2-Family Phage and Deep-Sea Shewanella putrefaciens. Environmental Microbiology. 2019, 1(11), 4212-4232

37.Guo YX+, Sun CL+, Li YM, Tang KH, Ni SW, Wang XX*. Antitoxin HigA inhibits virulence gene mvfR expression in Pseudomonas aeruginosa. Environmental Microbiology. 2019, 21(8), 2707-2723

36.Zhan WE, Yao JY, Tang KH, Li YM, Guo YX*, Wang XX*. Characterization of Two Toxin-Antitoxin Systems in Deep-Sea Streptomyces sp. SCSIO 02999. Marine Drugs. 2019, 17(4), 211

35.Li Y, Liu X, Tang KH, Wang PX, Zeng ZS, Guo YX, Wang XX*. Excisionase in Pf Filamentous Prophage Controls Lytic-lysogeny Decision-making in Pseudomonas aeruginosa. Molecular Microbiology. 2019, 111(2), 495-513

34.Tang KH, Wang Y, Wang XX*. Recent progress on signalling molecules of coral-associated microorganisms. Science China Earth Sciences. 2019, 62 (4), 609–618

33.Tao Liu, Zhangwei Guo, Zhenshun Zeng, Guo Na, Lei Yanhua, Liu Tong, Sun Shibin, Chang Xueting, Yin Yansheng, Xiaoxue Wang*. Marine Bacteria Provide Lasting Anti-Corrosion Activity for Steel via Biofilm-induced Mineralization. ACS Applied Materials & Interfaces. 2018,10 (46):40317-40327

32.Jianyun Yao, Yunxue Guo, Pengxia Wang, Zhenshun Zeng, Baiyuan Li, Kaihao Tang,Xiaoxiao Liu and Xiaoxue Wang*. Type II toxin/antitoxin system ParESO /CopASO stabilizes prophage CP4So in Shewanella oneidensis. Environmental Microbiology. 2018,20,1224-1239

31.Xuanyan Jia+, Jianyun Yao+, Zengqiang Gao, Guangfeng Liu, Yu-Hui Dong, xiaoxue Wang,* and Heng Zhang*. Structure-function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN-MNT toxin-antitoxin. Journal of Biological Chemistry. 2018,293,6812-6823

30.Wang P, Zeng Z, Wang W, Wen Z, Li J,  Wang X*.  (2017) Dissemination and Loss of a Biofilm-related Genomic Island in Marine Pseudoalteromonas Mediated by Integrative and Conjugative Elements. Environmental Microbiology 19(11), 4620–4637

29.Guo Y, Liu X, Li B, Yao J, Wood TK, Wang X*. (2017) Tail-Anchored Inner Membrane Protein ElaB Increases Resistance to Stress While Reducing Persistence in Escherichia coli. Journal of Bacteriology 199(9):e00057-17

28.Zeng Z#, Cai X#, Wang P, Guo Y, Liu X, Li B, Wang X*. (2017) Biofilm Formation and Heat Stress Induce Pyomelanin Production in Deep-Sea Pseudoalteromonas sp. SM9913. Frontiers in Microbiology 8:(1822)

27.Zeng Z#, Guo X#, Cai X, Wang P, Li B, Yang J*, Wang X*.  (2017) Pyomelanin from Pseudoalteromonas lipolytica reduces biofouling. Microbial Biotechnology 10(6):1718-1731

26.Sun C, Guo Y, Tang K, Wen Z, Li B, Zeng Z, Wang X*.  (2017) MqsR/MqsA Toxin/Antitoxin System Regulates Persistence and Biofilm Formation in Pseudomonas putida KT2440. Frontiers in Microbiology 8:(840)

25.Wen Z#, Wang P#, Sun C, Guo Y, Wang X*. (2017) Interaction of type IV toxin/antitoxin systems in cryptic prophages of Escherichia Coli K-12. Toxins 9:77

24.郭云学,李百元,王晓雪*. (2017) 细菌的毒素-抗毒素系统:定时炸弹还是免死金牌. 微生物学报 57(11): 1708-1715

23.Wang X*, Wood TK*. (2016). Cryptic Prophages as Targets For Drug Development. Drug Resistance Updates 27: 30-38

22.Zeng Z, Liu X, Yao J, Guo Y, Li B, Li Y, Jiao N, Wang X*. (2016). Cold adaptation regulated by cryptic prophage excision in Shewanella oneidensis. The ISME Journal doi:10.1038/ismej.2016.85.

21.Guo Y#*, Yao J#, Sun C, Wen Z, Wang X*. (2016)Characterization of the Deep-Sea Streptomyces sp. SCSIO 02999 Derived VapC/VapB Toxin-Antitoxin System in Escherichia coli. Toxins 8, 195.

20.Li B, Wang P, Zeng Z, Cai X, Wang G, Wang X*. (2016). Complete genome sequence of Pseudoalteromonas rubra SCSIO 6842, harboring a putative conjugative plasmid pMBL6842. Journal of biotechnology 224, 66-67.

19.Wang P, Wen Z, Li B, Zeng Z, Wang X*. (2016). Complete genome sequence of Vibrio alginolyticus ATCC33787T isolated from seawater with three native megaplasmids. Marine Genomics. 10.1016/j.margen.2016.05.003

18.Zeng Z, Guo X P, Li B, Wang P, Cai X, Tian X, Zhang S, Yang J, Wang X*. (2015). Characterization of self-generated variants in Pseudoalteromonas lipolytica biofilm with increased antifouling activities. Applied microbiology and biotechnology, 99(23): 10127-10139.

17.Liu X#, Li Y#, Guo Y, Zeng Z, Li B, Wood TK, Cai X, Wang X*. (2015). Physiological function of rac prophage during biofilm formation and regulation of rac excision in Escherichia coli K-12. Scientific Reports, 5:16074.

16.Yao J#, Guo Y#, Zeng Z, Liu X, Shi F, Wang X*. (2015). Identification and characterization of a HEPN-MNT family type II toxin–antitoxin in Shewanella oneidensis. Microbial Biotechnology 6:961-73.

15.Wang P, Yu Z, Li B, Cai X, Zeng Z, Chen X, Wang X*. (2015). Development of an efficient conjugation-based genetic manipulation system for Pseudoalteromonas. Microbial Cell Factories 14:11.

14.Jiao N, Legendre L, Robinson C, Thomas H, Luo Y-W, Dang H, Liu, J, Tang K, Luo T, Li C, Wang X, Zhang C. (2015). Comment on “Dilution limits dissolved organic carbon utilization in the deep ocean”. Science 350: 6267 1483-a. 

13.Guo Y, Quiroga C, Chen Q, McAnulty M, Benedik MJ, Wood TK*,Wang X*. (2014) RalR (a DNase) and RalA (a small RNA) form a type I toxin-antitoxin system in Escherichia coli.  Nucleic Acids Research, 42(10):6448-6462. (*Corresponding author)  

12.Wang X*, Lord DM, Hong SH, Peti W, Benedik MJ, Page R, Wood TK. (2013). Type II toxin-antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS. Environmental Microbiology, 15: 1734-1744. 

11.Wang X*, Lord DM*, Cheng HY*, Osbourne DO, Hong SH, Sanchez-Torres V, Quiroga C, Zheng K, Herrmann T, Peti W, Benedik MJ, Page R, Wood TK. (2012). A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nature Chemical Biology, 8: 855-61. (*equal contribution)  

10.Hong SH, Hegde M, Kim J, Wang X, Jayaraman A, Wood TK. (2012). Synthetic Quorum Sensing circuit to control consortial biofilm formation and dispersal in a microfluidic device. Nature Communications, 3: 613.

9. Hong SH, Wang X, O’Connor H, Benedik MJ, Wood TK. (2012).Bacterial persistence increases as environmental fitness decreases. Microbial Biotechnology, 5: 509-22.  

8. Wang X, Kim Y, Hong SH, Ma Q, Brown BL, Pu M, Tarone AM, Benedik MJ, Peti W, Page R, Wood TK. (2011). Antitoxin MqsA helps mediate the bacterial general stress response. Nature Chemical Biology, 7: 359-366.  

7. Wang X, Wood TK. (2011).  Toxin/antitoxin systems influence biofilm and persister cell formation and the general stress response. Applied and Environmental Microbiology, 77: 5577-5583.  

6. Wang X, Wood TK. (2011). IS5 inserts upstream of flhDC in a quasi-Lamarckian way. The ISME Journal, 5: 1517–1525.  

5. Wang X, Kim Y, Ma Q, Hong SH, Pokusaeva K, Sturnio JM, Wood TK. (2010). Cryptic prophages help bacteria cope with adverse environments. Nature Communications , 1: 147.  

4. Kim Y, Wang X, Zhang XS, Page R, Peti W, Wood TK. (2010). Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. Environmental Microbiology, 12: 1105-1121. 

3. Hong SH, Wang X, Wood TK. (2010). Controlling biofilm formation, prophage excision, and cell death rewiring global regulator H-NS of Escherichia coliMicrobial Biotechnology, 3: 344-356  

2. Wang X, Kim Y, Wood TK. (2009). Control and benefits of CP4-57 prophage excision in Escherichia coli biofilms. The ISME Journal, 3: 1164-1179.  

1. Kim Y, Wang X, Ma Q, Zhang XS, Wood TK. (2009). Toxin-antitoxin systems in Escherichia coli influence biofilm formations through YjgK (TabA) and fimbriae. Journal of Bacteriology, 191: 1258-1267.