研究生培养
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所系名称 |
中国科学院南海海洋研究所，中国科学院热带海洋生物资源与生态重点实验室 | ||||
性别 |
男 | ||||
专业名称 |
海洋生物学 | ||||
技术职务 |
责任研究员 | ||||
行政职务 |
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Mail地址 |
yyan@scsio.ac.cn | ||||
指导博士生总数 |
0 |
指导硕士生总数 |
0 |
通讯地址 |
广州市海珠区新港西路164号5号楼 |
目前博士生数 |
0 |
目前硕士生数 |
0 |
邮政编码 |
510301 |
研究方向 |
链霉菌和真菌来源的活性天然产物的研究。 |
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研究工作 |
发展了以多样性为导向的合成生物学策略并建立了天然产物类似物分子库，显著提升了天然活性分子的高通量筛选效率。相关工作以第一作者分别发表在Organic Letters和Angewandte Chemie International Edition，并以共同第一作者发表在Journal of the American Chemical Society杂志上；其次，阐明了狄尔斯-阿尔德环加成反应构建螺环乙酰乙酸内酯/内酰胺抗感染抗生素分子骨架的酶学机制，相关工作以共同第一作者将该研究成果发表在Nature Chemical Biology杂志上；第三，发展了以抗性基因为导向的“基因组挖掘”技术并成功用于新型除草剂的开发，通过深入研究实现了使用aspterric acid (AA)选择性除草而不伤害作物的功效，AA除草剂的发现填补了杜邦公司二十多年来在开发新型抑制支链氨基酸途径除草剂领域的空白，同时也将打破全世界在近30年未曾有新型作用机制除草剂问世的局面，重创了国际农业巨头对抗除草剂转基因作物种子的垄断供应，具有重大的经济价值。作为第一作者完成了这项科研成果并发表在国际顶级学术期刊Nature上，并申请了相关专利。这一成果得到了业内专家和学者们的一致好评。 | ||||
获奖情况 |
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指导研究生情况 |
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个人简介 |
学习经历
工作经历 |
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科研成果 |
1. Yan Yan#, Qikun Liu#, Xin Zang#, Shuguang Yuan, Undramaa Bat-Erdene, Calvin Nguyen, Jianhua Gan, Jiahai Zhou*, Steven E. Jacobsen*, Yi Tang*. Resistance-gene directed discovery of a natural product herbicide with a new mode of action, Nature; 2018, 559: 415-418 2. Yan Yan, Jing Chen, Lihan Zhang, Qingfei Zheng, Ying Han, Hua Zhang, Daozhong Zhang, Takayoshi Awakawa, Ikuro Abe, and Wen Liu*. Multiplexing of combinatorial chemistry in antimycin biosynthesis expands the molecular diversity and utility, Angew. Chem. Int. Ed., 2013, 52: 12308-12312 3. Zhenhua Tian#, Peng Sun#, Yan Yan#, Zhuhua Wu, Qinfei Zheng, Shuaixiang Zhou, Hua Zhang, Futao Yu, Xinying Jia, Dandan Chen, Attila Mandi, Tibor Kurtan, Wen Liu*. An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins, Nat. Chem. Biol., 2015, 11: 259-265 4. Chenchen Chang#, Rong Huang#, Yan Yan#, Hongmin Ma, Zheng Dai, Benying Zhang, Zixin Deng, Wen Liu, Xudong Qu*. Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into polyketide carbon scaffolds, J. Am. Chem. Soc., 2015, 137: 4183–4190 5. Yan Yan, Qikun Liu, Steven E. Jacobsen, Yi Tang*. The impact and prospect of natural product discovery in agriculture, EMBO Rep, 2018, 19: e46824 6. Yan Yan, Lihan Zhang, Takuya Ito, Xudong Qu, Yoshinori Asakawa, Takayoshi Awakawa, Ikuro Abe, Wen Liu*. Biosynthetic pathway for high structural diversity of a common dilactone core in antimycin production, Org. Lett., 2012, 14: 4142–4145 7. Lihan Zhang, Takahiro Mori, Qingfei Zheng, Takayoshi Awakawa, Yan Yan, Wen Liu, Ikuro Abe*. Rational control of polyketide extender units by structure-based engineering of a crotonyl-CoA carboxylase/reductase in antimycin biosynthesis, Angew. Chem. Int. Ed.; 2015, 54: 13462-13465 8. Lihan Zhang, Jing Chen, Takahiro Mori, Yan Yan, Wen Liu, Ikuro Abe*. Crystallization and preliminary X-ray diffraction analysis of AntE, a crotonyl-CoA carboxylase/reductase from Streptomyces sp. NRRL 2288, Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 2014, 70: 734-737 |
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